You asked for it, you got it.

Parkinson's Disease strikes the neurons of the Nigrostriatal pathway, that is, the dopamine-releasing neurons whose cell bodies reside in the Substantia Nigra and synapse in the striatum (also known as the caudate/putamen). You generally have to lose about 90% of those neurons to get any symptoms. Really. The CNS covers its own a$$.

Interestingly enough, Huntington's Disease strikes the reciprocal connections, from the caudate to the SN, and elsewhere.....

Here's a brainstem cross-section of a PD patient and a person who died from something else. Not surprisingly, the substantia nigra is the black band near the bottom-middle.

Posted by: caltechgirl at 10:59 AM | Comments (1) | Add Comment
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